Amsterdam's oldest Catholic church, St. Mary's, began along the South Side of the city. Conforming to a history of St. Mary's written by Jacqueline Daly Murphy, a priest from Schenectady came to say Mass for Irish Catholics working on the Erie Canal east of Amsterdam in 1839.
In 1849, Catholics purchased the earlier St. Ann's Episcopal Church onward the South Side of the river from Amsterdam, a composition of differences then called Port Jackson. The new church was named St. Mary's moreover Reverend Daniel Cull was pastor. In 1869, St. Mary's moved across the river to its make public location forward East Main Street where a new church was built.
While St. Mary's primarily served the Irish, in 1883 it was reported that confessions were beingness heard there in Italian, Spanish, Latin, French, Hungarian along with German.